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Updated: Apr 16, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
Published on: June 5, 2010
Low-load resistance training promotes muscular adaptation regardless of vascular occlusion, load, or volume
Larissa Corrêa Barcelos1, Paulo Ricardo Prado Nunes, Luís Ronan Marquez Ferreira de Souza
1Exercise Biology Laboratory (BioEx), Federal University of Triangulo Mineiro (UFTM), Av. Tutunas, 490, Uberaba, Minas Gerais, 38061-500, Brazil.
Purpose:
This study investigates the impact of two different intensities and different volumes of low-load resistance training (LLRT) with and without blood flow restriction on the adaptation of muscle strength and size.
Methods:
The sample was divided into five groups: one set of 20 % of one repetition maximum (1RM), three sets of 20 % of 1RM, one set of 50 % of 1RM, three sets of 50 % of 1RM, or control. LLRT was performed with (OC) or without (NOC) vascular occlusion, which was selected randomly for each subject. The maximal muscle strength (leg extension; 1RM) and the cross-sectional area (quadriceps; CSA) were assessed at baseline and after 8 weeks of LLRT.
Results:
1RM performance was increased in both groups after 8 weeks of training: OC (1 × 50 % = 20.6 %; 3 × 50 % = 20.9 %; 1 × 20 % = 26.6 %; 3 × 20 % = 21.6 %) and NOC (1 × 50 % = 18.6 %; 3 × 50 % = 26.8 %; 1 × 20 % = 18.5 %; 3 × 20 % = 21.6 %; 3 × 20 % = 24.7 %) compared with the control group (-1.7 %). Additionally, the CSA was increased in both groups: OC (1 × 50 % = 2.4 %; 3 × 50 % = 3.8 %; 1 × 20 % = 4.6 %; 3 × 20 % = 4.8 %) and NOC (1 × 50 % = 2.4 %; 3 × 50 % = 1.5 %; 1 × 20 % = 4.3 %; 3 × 20 % = 3.8 %) compared with the control group (-0.7 %). There were no significant differences between the OC and NOC groups.
Conclusion:
We conclude that 8 weeks of LLRT until failure in novice young lifters, regardless of occlusion, load or volume, produces similar magnitudes of muscular hypertrophy and strength.
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