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Updated: Apr 16, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
The difficult in vitro fertilization patient: an individualized approach
David Reichman1, Zev Rosenwaks1
1The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
Standardized in vitro fertilization (IVF) may not work for all patients. This article discusses personalized IVF treatment approaches for women who require highly individualized care for better success rates.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization
- Personalized Medicine
Background:
- Standardized in vitro fertilization (IVF) protocols are widely successful for most patients.
- However, a subset of women do not achieve success with conventional IVF approaches.
- These patients often require tailored treatment strategies.
Purpose of the Study:
- To outline personalized treatment approaches for challenging IVF cases.
- To share clinical experience with individualized IVF protocols.
- To improve success rates for patients not responding to standard regimens.
Main Methods:
- Review of clinical experience with non-standard IVF protocols.
- Description of individualized treatment modifications.
- Case-based examples of tailored approaches.
Main Results:
- Personalized IVF protocols can be effective for "difficult to treat" patients.
- Individualized adjustments to stimulation, monitoring, or laboratory procedures are key.
- Successful outcomes were observed in cases where standard protocols failed.
Conclusions:
- Highly individualized IVF treatment is crucial for specific patient populations.
- Clinicians should consider tailored approaches beyond standardized protocols.
- Personalized medicine enhances IVF success in challenging cases.
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