Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethyl glucuronide and ethyl sulfate.

Natalie E Walsham1, Roy A Sherwood2

  • 1Department of Clinical Biochemistry, University Hospital Lewisham, London, United Kingdom.

Advances in Clinical Chemistry
|March 5, 2015
PubMed
Summary

Ethyl glucuronide (EtG) is a novel biomarker for detecting excessive alcohol consumption. This metabolite is detectable in urine and hair, offering a valuable tool for identifying recent heavy drinking episodes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer's disease.

Wellcome open research·2022
Same author

The association of depressive symptoms and diabetes distress with glycaemic control and diabetes complications over 2 years in newly diagnosed type 2 diabetes: a prospective cohort study.

Diabetologia·2017
Same author

A randomized double-blind placebo-controlled trial of a multi-strain probiotic in treatment of symptomatic uncomplicated diverticular disease.

Inflammopharmacology·2017
Same author

Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants-single centre pilot study.

Journal of clinical pathology·2017
Same author

Elevated fasting and postprandial C-terminal telopeptide after Roux-en-Y gastric bypass.

Annals of clinical biochemistry·2016
Same author

Clinical relevance of trace element measurement in patients on initiation of parenteral nutrition.

Annals of clinical biochemistry·2016

Area of Science:

  • Clinical Chemistry
  • Toxicology
  • Biomarker Discovery

Background:

  • Alcohol misuse leads to significant health problems.
  • Current methods for detecting alcohol misuse, like self-reports, are often unreliable due to under-reporting.
  • Existing biomarkers primarily detect acute or chronic alcohol use, with a gap for intermediate detection.

Purpose of the Study:

  • To evaluate ethyl glucuronide (EtG) as a biomarker for detecting excessive alcohol consumption.
  • To assess EtG's utility in identifying recent alcohol intake, particularly binge drinking.
  • To explore the application of EtG in clinical and forensic settings.

Main Methods:

  • Measurement of ethyl glucuronide (EtG) in biological samples (urine and hair).
  • Analysis of EtG's detection window for recent alcohol consumption.
Keywords:
Alcohol dependenceAlcohol markersEthyl glucuronideEthyl sulfateFetal alcohol syndrome

Related Experiment Videos

  • Assessment of EtG's specificity for excessive alcohol intake.

    • Main Results:

    • Ethyl glucuronide (EtG) is a direct metabolite of ethanol.
    • EtG is detectable in urine for up to 90 hours and in hair for longer periods.
    • EtG demonstrates high specificity for excessive alcohol consumption, including binge drinking.

    Conclusions:

    • EtG is a promising noninvasive biomarker for detecting recent excessive alcohol intake.
    • The detection of EtG in urine and hair supports its use in clinical and forensic contexts.
    • EtG offers a valuable tool for monitoring alcohol consumption patterns between acute and chronic markers.