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Updated: Apr 16, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Circulating microRNAs as Promising Tumor Biomarkers
Meng Chen1, George A Calin2, Qing H Meng1
1Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Circulating microRNAs (miRNAs) show promise as cancer biomarkers for diagnosis and treatment. Research highlights their role in tumorigenesis and potential for personalized medicine applications.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression.
- Dysregulation of miRNAs is linked to tumorigenesis and cancer development.
- Circulating miRNAs are emerging as non-invasive biomarkers for various cancers.
Purpose of the Study:
- To review the origin and function of circulating miRNAs.
- To compare high-throughput technologies for miRNA quantitation.
- To summarize recent findings on miRNAs as cancer biomarkers.
Main Methods:
- Literature review of recent publications on circulating miRNAs.
- Analysis of high-throughput technologies for miRNA detection.
- Summary of miRNA applications in cancer diagnosis, prognosis, and treatment response.
Main Results:
- Circulating miRNAs are involved in key cellular processes relevant to cancer.
- High-throughput technologies offer advanced miRNA quantitation methods.
- miRNAs show potential as biomarkers for prostate, breast, lung, colorectal, and hematological cancers.
Conclusions:
- Circulating miRNAs hold significant translational potential for personalized cancer medicine.
- Accurate measurement and clinical application of circulating miRNAs require addressing current limitations.
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