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Proteomics in transplantation

Katrin Kienzl-Wagner1, Gerald Brandacher2

  • 1Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.

Advances in Clinical Chemistry
|March 5, 2015
PubMed

Proteomics and biochemical profiling have emerged as exciting and powerful tools in clinical biomarker research. In the field of transplantation, proteomics aims not only at developing noninvasive means for immune monitoring but also to gain mechanistic insights into the pathophysiology of the alloimmune response and hence defining new therapeutic targets. This chapter provides an overview of proteomic biomarker-driven approaches and its underlying concepts and discusses the advantages, clinical implications, challenges, and limitations of this novel modality as it relates to solid organ transplantation.

Keywords:
BiomarkerDiagnosisImmunosuppressionProteomicsRejectionTransplantation

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