Related Experiment Video
Updated: Apr 16, 2026
02:08
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
Published on: July 5, 2024
1.7K
Bone cells and bone turnover in diabetes mellitus
1Department of Medicine, Metabolic Bone Diseases Unit, College of Physicians and Surgeons, Columbia University, 630 W. 168th St, New York, NY, 10032, USA, mrr6@columbia.edu.
Current Osteoporosis Reports
|March 6, 2015
Summary
Diabetes increases fracture risk due to altered bone remodeling. Biochemical markers like P1NP and osteocalcin are decreased, while sclerostin is increased in type 2 diabetes, predicting fractures independently of bone density.
Area of Science:
- Endocrinology
- Metabolic Bone Disease
- Diabetology
Background:
- Diabetes mellitus is associated with numerous complications.
- Increased fracture risk is a significant morbidity in diabetes, potentially linked to impaired bone remodeling and cellular function.
- Altered bone metabolism in diabetes affects both bone formation and resorption.
Purpose of the Study:
- To investigate the relationship between type 2 diabetes (T2D) and fracture risk.
- To explore the role of specific biochemical markers of bone turnover in T2D-related fractures.
- To examine potential contributing factors to bone fragility in diabetic patients.
Main Methods:
- Analysis of circulating biochemical markers of bone formation (P1NP, osteocalcin, bone-specific alkaline phosphatase) and resorption (serum CTx).
- Assessment of serum sclerostin levels.
- Consideration of factors like bone marrow fat saturation, advanced glycation endproduct (AGE) accumulation, and microarchitectural changes.
- Correlation of marker levels with fracture risk, independent of bone mineral density (BMD).
Main Results:
- Decreased levels of bone formation markers (P1NP, osteocalcin, bone-specific alkaline phosphatase) observed in T2D.
- Reduced levels of the bone resorption marker serum CTx reported in T2D.
- Increased serum sclerostin levels found in T2D, showing predictive value for fracture risk independent of BMD.
- Preliminary histomorphometric data support these findings.
Conclusions:
- Type 2 diabetes is associated with altered bone remodeling, characterized by reduced bone formation and potentially altered resorption.
- Specific biochemical markers, including decreased P1NP and increased sclerostin, may predict fracture risk in T2D independently of BMD.
- Factors such as AGEs and microarchitectural changes may further contribute to bone fragility in diabetes.
More Related Videos
Related Concept Videos
01:29Bone Disorders
8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K
01:40Bone Remodeling
41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K
01:31Osteoclasts in Bone Remodeling
4.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.9K
01:17Hormones and Bone Tissue
4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.3K
01:02What is the Skeletal System?
59.4K
Overview
59.4K
01:30Bone Cells and Tissue
14.1K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
14.1K