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Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

PATHOGENESIS OF PERSISTENT PLACOID MACULOPATHY: A Multimodal Imaging Analysis.

Melisa Nika¹, Partho S Kalyani, K Thiran Jayasundera

¹Department of Ophthalmology, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Retina (Philadelphia, Pa.)

|March 6, 2015

Summary

Persistent placoid maculopathy may stem from inner choroid inflammation. High-dose corticosteroids offer temporary relief for this rare eye condition.

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Last Updated: Apr 16, 2026

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Area of Science:

Ophthalmology
Retinal Diseases
Inflammatory Eye Conditions

Background:

Persistent placoid maculopathy (PPM) is a rare condition affecting the macula.
Understanding its pathogenesis and optimal management is crucial for visual preservation.

Observation:

A retrospective case series of three male patients aged 55-68 with bilateral PPM.
Previously undocumented findings included far-peripheral lesions and optic nerve hyperfluorescence on fluorescein angiography.
Recurrence and choroidal neovascularization were observed in one patient.

Findings:

Multimodal imaging suggested an inflammatory origin within the inner choroid, impacting the retinal pigment epithelium and outer retina.
All patients showed significant structural and functional improvement within weeks of initiating high-dose corticosteroids (0.75-1 mg/kg/day).

Implications:

Multimodal imaging supports an inflammatory basis for PPM, potentially originating in the inner choroid.
High-dose corticosteroids demonstrate short-term efficacy in managing persistent placoid maculopathy.
Further research into the long-term effects and alternative treatments for PPM is warranted.