Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Predictive Value of TMJ Tomographic Parameters for Hypermobility-Related Outcomes and Mouth Opening Capacity.

Journal of oral rehabilitation·2026

Same author

Clinical and psychosocial predictors of treatment expectations in Brazilian patients with temporomandibular disorders: A retrospective cohort study.

Journal of psychosomatic research·2026

Same author

Psychological Features Associated With Awake Bruxism in Painful TMD: The Role of Anxiety.

Journal of oral rehabilitation·2026

Same author

Association between mouth opening pattern and facial skeletal pattern: a retrospective analysis.

Dental press journal of orthodontics·2026

Same author

Predictive Value of Diagnostic Methods for TMJ Hypermobility in the Associated Clinical and Functional Features of Temporomandibular Disorders: A Regression Study.

Journal of oral rehabilitation·2025

Same author

Impact of Posterior Single Tooth Loss on Oral Health-Related Quality of Life and Single-Unit Immediate Implant Loading: Six-Month Follow-up Study.

Journal of long-term effects of medical implants·2025

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

TMD and chronic pain: a current view.

Bruno D'Aurea Furquim¹, Lívia Maria Sales Pinto Flamengui², Paulo César Rodrigues Conti³

¹University of São Paulo.

Dental Press Journal of Orthodontics

|March 6, 2015

Summary

Temporomandibular disorders (TMDs) involve distinct mechanisms for joint pain versus chronic muscle pain. Central sensitization, influenced by genetics and the nervous system, is key to understanding complex TMD symptoms.

More Related Videos

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Apr 16, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

Area of Science:

Dentistry
Pain Medicine
Rheumatology

Background:

Temporomandibular disorders (TMDs) encompass a range of conditions affecting the jaw joint and muscles.
Understanding the underlying physiopathology is crucial for effective diagnosis and treatment.

Purpose of the Study:

To review the current physiopathologic mechanisms of TMDs.
To differentiate between joint and muscle pain mechanisms in TMDs.
To highlight the role of central sensitization in chronic TMD pain.

Main Methods:

Literature review of studies on TMD physiopathology.
Analysis of inflammatory pathways in TMD joint pain.
Examination of functional pain mechanisms in TMD muscle pain.

Main Results:

TMD joint pain is linked to inflammatory processes involving tumor necrosis factor-α and interleukin.
Chronic TMD muscle pain exhibits complex, enigmatic mechanisms, resembling functional pain syndromes.
Central sensitization is identified as a unifying factor in these chronic pain conditions.

Conclusions:

TMD symptoms arise from a complex interplay of factors.
Central sensitization, influenced by the autonomic nervous system and genetic factors, plays a significant role.
Individual adaptation significantly impacts TMD symptom severity.