Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structurally Defined Low-Coordination Single-Atom Strategy for CO<sub>2</sub> Photoconversion to Formic Acid.

Journal of the American Chemical Society·2026
Same author

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

VALD-3 Induces GSDME-Dependent Pyroptosis via ROS/JNK/Bax Pathway in Triple-Negative Breast Cancer Cells.

Biochemical genetics·2026
Same author

Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.

Scientific reports·2026
Same author

Amino acid infusion and acute kidney injury after aortic surgery: a multicenter observational study with target trial emulation.

Renal failure·2026
Same author

Functional Ultrasound Localization Microscopy on Freely Moving Rats.

Research square·2026
Same journal

A pump-free gravity-driven microfluidic chip for rapid RPA-LFS-based detection of Magnaporthe oryzae AvrPi9 gene.

Biomedical microdevices·2026
Same journal

Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours.

Biomedical microdevices·2026
Same journal

Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.

Biomedical microdevices·2026
Same journal

3D printed chip as platform to vascularize hiPSCs-derived kidney organoids.

Biomedical microdevices·2026
Same journal

Ingestible smart capsules: from engineering innovation to GI drug delivery.

Biomedical microdevices·2026
Same journal

An inexpensive, portable, refrigeration-free, ready-to-use microfluidic device for real-time multiplexed molecular detection of HIV, HBV, and HCV.

Biomedical microdevices·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion
10:23

Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion

Published on: May 2, 2013

10.4K

A microfluidic device for efficient chemical testing using Caenorhabditis elegans.

Pengfei Song1, Weize Zhang, Alexandre Sobolevski

  • 1Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, Quebec, H3A 0C3, Canada.

Biomedical Microdevices
|March 7, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a microfluidic device for chemical testing on Caenorhabditis elegans (C. elegans) nematodes. The system enables precise environmental control and automated locomotion analysis for efficient biological research.

More Related Videos

A Simple Microfluidic Chip for Long-Term Growth and Imaging of Caenorhabditis elegans
10:45

A Simple Microfluidic Chip for Long-Term Growth and Imaging of Caenorhabditis elegans

Published on: April 11, 2022

2.7K
Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons
07:31

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Published on: September 7, 2017

8.6K

Related Experiment Videos

Last Updated: Apr 16, 2026

Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion
10:23

Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion

Published on: May 2, 2013

10.4K
A Simple Microfluidic Chip for Long-Term Growth and Imaging of Caenorhabditis elegans
10:45

A Simple Microfluidic Chip for Long-Term Growth and Imaging of Caenorhabditis elegans

Published on: April 11, 2022

2.7K
Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons
07:31

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Published on: September 7, 2017

8.6K

Area of Science:

  • Biotechnology
  • Neuroscience
  • Developmental Biology

Background:

  • Caenorhabditis elegans is a widely used model organism in biological research.
  • Accurate chemical testing on nematodes is crucial for understanding biological responses.

Purpose of the Study:

  • To develop and validate a microfluidic device for precise chemical environment control and automated locomotion analysis of single C. elegans.
  • To enhance the efficiency and accuracy of chemical screening using C. elegans.

Main Methods:

  • A microfluidic device with individual chambers for single nematode housing.
  • Precise control of the chemical microenvironment within each chamber.
  • A custom software with a GUI for quantitative analysis of nematode locomotion parameters (e.g., swimming frequency, bend amplitude).
  • Gentle and rapid loading of up to eight nematodes.

Main Results:

  • The microfluidic device successfully houses single C. elegans in controlled chemical environments.
  • Automated analysis of locomotion parameters was achieved, enhancing data collection efficiency.
  • Proof-of-concept experiments with zinc ions and glucose demonstrated the device's effectiveness.

Conclusions:

  • The developed microfluidic device offers a powerful platform for chemical testing on C. elegans.
  • This technology facilitates high-throughput and quantitative analysis of nematode behavior in response to stimuli.
  • The system has broad applications in toxicology, pharmacology, and neurobiology research.