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Updated: Apr 16, 2026
07:29
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
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[Glucose homeostasis and gut-brain connection]
Filipe De Vadder1, Gilles Mithieux1
1Inserm U855, 7-11 rue Paradin, 69372 Lyon Cedex 08, France ; Université de Lyon, 69008 Lyon, France ; Université Lyon 1, 69622 Villeurbanne, France.
Medecine Sciences : M/S
|March 7, 2015
Summary
The brain and gut communicate through a neural axis to regulate hunger and energy balance. This gut-brain interaction is crucial for maintaining metabolic homeostasis and responding to nutrient signals.
Area of Science:
- Neuroscience
- Endocrinology
- Metabolism
Context:
- The brain's role in regulating food intake and glucose homeostasis has been recognized since the 19th century.
- Gut hormones have further elucidated the gut-brain axis's involvement in energy and glucose regulation.
- The hypothalamus and brainstem are key brain regions receiving metabolic information from peripheral organs and the gut.
Purpose:
- To review the neural pathways connecting the gut and brain.
- To describe how the interplay between the gut and brain regulates metabolic status and energy balance.
- To highlight the role of nutrients in controlling hypothalamic homeostatic functions via the gut-brain axis.
Summary:
- The gut-brain neural axis is a critical regulator of metabolic status.
- Nutrients influence hypothalamic homeostatic functions through this axis.
- The review details the neural connections between the gut and brain and their role in energy balance.
Impact:
- Provides a comprehensive overview of the gut-brain axis in metabolic regulation.
- Enhances understanding of how nutrient intake influences energy balance.
- Offers insights into potential therapeutic targets for metabolic disorders.
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