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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Apr 16, 2026

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

Myocardial T1 mapping.

Heerajnarain Bulluck¹, Viviana Maestrini, Stefania Rosmini

¹Heart Hospital Imaging Centre, Barts Heart Centre; Hatter Cardiovascular Institute, University College London.

Circulation Journal : Official Journal of the Japanese Circulation Society

|March 10, 2015

Summary

This summary is machine-generated.

T1 mapping in cardiovascular magnetic resonance imaging allows for the detection and quantification of diffuse myocardial diseases, offering new insights into various heart conditions. This technique shows promise for early diagnosis, disease severity assessment, and therapeutic monitoring.

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Last Updated: Apr 16, 2026

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Published on: July 19, 2013

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Area of Science:

Cardiology
Medical Imaging
Biophysics

Background:

Cardiovascular magnetic resonance (CMR) excels at quantifying focal fibrosis.
Diffuse myocardial processes were previously challenging to measure.
T1 mapping has emerged as a novel technique in CMR.

Purpose of the Study:

To review the current status of T1 mapping in cardiovascular magnetic resonance.
To explore the potential applications and challenges of T1 mapping for diffuse myocardial diseases.
To highlight T1 mapping's role in disease detection, quantification, and prognosis.

Main Methods:

Review of current literature on T1 mapping in cardiovascular magnetic resonance.
Discussion of T1 mapping's principles and applications in diffuse myocardial pathologies.
Analysis of T1 mapping's potential as a prognostic and surrogate marker.

Main Results:

T1 mapping enables detection and quantification of diffuse myocardial diseases, including infiltration, storage disorders, and diffuse fibrosis.
It offers potential for early disease detection, severity assessment, and prognostic insights.
T1 mapping may serve as a surrogate marker in drug development for monitoring therapeutic response.

Conclusions:

T1 mapping represents a significant advancement in assessing diffuse myocardial diseases using CMR.
It holds promise for improving patient outcomes and aiding therapeutic development.
Standardization of T1 mapping techniques remains an ongoing challenge.