[Certain opioids can preferably be administered transdermally]
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Updated: Oct 12, 2026

In Vivo SiRNA Transfection and Gene Knockdown in Spinal Cord via Rapid Noninvasive Lumbar Intrathecal Injections in Mice
Published on: March 22, 2014
Niels Martin Jensen1, Rikke Holmgaard, Jesper Bo Nielsen
1Plastikkirurgisk Afdeling Z, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense. nmjensen@health.sdu.dk.
Abstract:
Many patients experience acute or chronic pain. The options for treating these pain conditions are many, and particularly products for topical application are gaining ground. NSAID for topical use is a good alternative to NSAID administered orally due to less systemic side effects. Transdermally delivered opioids have proven to be as effective as morphine in pain management of chronic, moderate to severe pain. The steady delivery and lower risk of breakthrough pain overweigh the higher cost and risk of adverse events compared to the orally delivered opioids.
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