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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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Evaluating historical candidate genes for schizophrenia
M S Farrell1, T Werge2, P Sklar3
1Center for Psychiatric Genomics, Department of Genetics, Genomic Medicine, University of North Carolina, Chapel Hill, NC, USA.
Molecular Psychiatry
|March 11, 2015
Summary
Historical schizophrenia candidate gene studies, despite extensive effort, did not provide clear genetic insights. Inadequate statistical power likely hindered these early investigations, though they paved the way for modern genomic approaches.
Area of Science:
- Psychiatry
- Genetics
- Molecular Biology
Background:
- Candidate gene studies were a primary method for investigating schizophrenia genetics before the genome-wide association era.
- Numerous genes were proposed as candidates, with a focus on common variants contributing to schizophrenia risk.
Observation:
- An evaluation was conducted using meta-analysis of existing literature, incorporating data from large-scale genomic studies.
- Ratings from informed researchers and 24 schizophrenia geneticists were also included.
Findings:
- The historical candidate gene literature, despite extensive research, did not provide clear insights into schizophrenia's genetic underpinnings.
- Inadequate statistical power is identified as a probable cause for the limited success of these early studies.
Implications:
- Early candidate gene studies, though limited in direct findings, were crucial for establishing the foundation for modern genomic research in schizophrenia.
- Future research benefits from the groundwork laid by these historical investigations.
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