Patient-reported outcomes as end points and outcome indicators in solid tumours.

Area of Science:

• Oncology
• Clinical Trials
• Health Outcomes Research

Background:

• Patient-reported outcome (PRO) measures, including quality of life, are linked to clinical endpoints and survival in adult solid cancers.
• PROs are gaining influence, challenging traditional endpoints that may not fully capture therapy benefits, risks, and costs.

Purpose of the Study:

• To review the correlation between PROs and treatment response and survival in cancer clinical trials.
• To explore composite endpoints that integrate tumor-related and patient-centric data.

Main Methods:

• Comprehensive literature review assessing the association of PROs with clinical outcomes.
• Exploration of composite endpoint methodologies in cancer clinical trials.

Main Results:

• PROs demonstrate prognostic value and association with clinical endpoints in various adult solid cancers.
• PROs provide a more holistic view of therapeutic impact compared to traditional endpoints alone.

Conclusions:

• Composite endpoints combining tumor-related and PRO data can enhance understanding of overall therapeutic benefit.
• These integrated endpoints can aid healthcare providers, patients, and decision-makers in evaluating cancer interventions.