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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
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Chronic hepatitis e virus infection and treatment
Nassim Kamar1, Jacques Izopet2, Harry R Dalton3
1Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France ; INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France ; Université Paul Sabatier, Toulouse, France.
Journal of Clinical and Experimental Hepatology
|March 11, 2015
Summary
Hepatitis E virus (HEV) infection can cause chronic liver disease in immunocompromised individuals. Treatment involves reducing immunosuppression or antiviral therapies like interferon and ribavirin.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Hepatitis E virus (HEV) infection is increasingly recognized as a cause of chronic hepatitis and cirrhosis.
- Chronic HEV infections primarily affect immunosuppressed patients, including solid-organ transplant recipients, those with hematological diseases, and individuals with human immunodeficiency virus (HIV).
- HEV can also lead to extra-hepatic manifestations affecting neurological, renal, and hematological systems.
Purpose of the Study:
- To review current knowledge on chronic HEV infection in specific patient populations.
- To summarize effective treatment strategies for chronic HEV.
- To discuss HEV-associated extra-hepatic manifestations.
Main Methods:
- Literature review of studies on chronic HEV infection.
- Analysis of treatment outcomes in different patient groups.
- Compilation of reported extra-hepatic manifestations.
Main Results:
- Chronic HEV is well-established in immunosuppressed patients, particularly transplant recipients.
- Reducing immunosuppression can clear HEV in some transplant patients.
- Antiviral therapies (pegylated interferon, ribavirin) are effective for HEV eradication in non-responders and other at-risk groups.
Conclusions:
- Chronic HEV infection poses a significant challenge in immunosuppressed populations.
- Management requires tailored approaches, including immunosuppression adjustment and antiviral therapy.
- Understanding and managing extra-hepatic manifestations is crucial for comprehensive patient care.
Keywords:
CSF, cerebrospinal fluidHEV, hepatitis E virusHIV, human immunodeficiency virusSOT, solid-organ transplantchronic infectioncirrhosisextra-hepatic symptomshepatitis E virusribavirinMore Related Videos
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