Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamic Responses: Different Types01:03

Pharmacodynamic Responses: Different Types

141
Pharmacodynamics is the scientific study of a drug's biochemical or physiological influence on the body. It categorizes responses into continuous, discrete (or categorical), and time-to-event outcomes. Continuous responses yield numerical values within a certain range, such as blood pressure readings and blood glucose levels, gauging the efficacy of antihypertensive and antidiabetic drugs. Discrete responses can be binary, indicating whether a drug has an effect or not, or ordinal, exemplifying...
141
The Response of Equilibria to the Conditions01:30

The Response of Equilibria to the Conditions

83
Named after the French chemist Henry Louis Le Chatelier, Le Chatelier's principle states that when a system at equilibrium is subjected to any change (like pressure, temperature, or concentration), the composition of the system adjusts in a way that counteracts the effect of this change, thereby attempting to restore the equilibrium.According to Le Chatelier's principle, for exothermic reactions, when the system's temperature is increased, the system will try to reduce the temperature. This...
83
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model01:29

Pharmacodynamic Models: Direct Effect Model and Indirect Response Model

135
Pharmacodynamic models are essential tools in understanding the relationship between drug concentrations and their effects on biological systems. By characterizing the dynamics of drug action, these models guide dose selection, optimize therapeutic efficacy, and inform the development of new drugs. Two major classes of pharmacodynamic models include direct effect and indirect response models.Direct Effect ModelsDirect effect models describe the immediate relationship between drug concentration...
135
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

953
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
953
Pharmacokinetic–Pharmacodynamic Relationship: Problems01:24

Pharmacokinetic–Pharmacodynamic Relationship: Problems

104
The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
104
Reaction Quotient02:35

Reaction Quotient

55.7K
The status of a reversible reaction is conveniently assessed by evaluating its reaction quotient (Q). For a reversible reaction described by m A + n B ⇌ x C + y D, the reaction quotient is derived directly from the stoichiometry of the balanced equation as
55.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report.

Bipolar disorders·2026
Same author

Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Validation and Extension of a Risk Calculator to Predict Mood Recurrence in Young People with Bipolar Disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Agreement between smartphone-based mobile sensing and actigraphy sleep metrics in young people with bipolar disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Effective connectivity of implicit emotion processing in adolescent psychiatric inpatients: Dynamic causal modeling across bipolar disorder and other psychopathologies.

Journal of affective disorders·2026
Same author

Reinforcement Learning and Decision Making in Depression in Adolescents and Young Adults: Insights from a New Model of the Probabilistic Reward Task.

Computational psychiatry (Cambridge, Mass.)·2026
Same journal

Global Prevalence of Obsessive-Compulsive and Related Disorders: A Systematic Review and Modeling Study.

The American journal of psychiatry·2026
Same journal

Treatment Patterns and Barriers to Care Among U.S. Adults With Co-Occurring Substance Use Disorder and Mental Illness.

The American journal of psychiatry·2026
Same journal

Implantable Neuromodulation Devices in Psychiatry: Human Fidelity and Implementation Challenges.

The American journal of psychiatry·2026
Same journal

Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety.

The American journal of psychiatry·2026
Same journal

2026 Annual Meeting: President-Elect Address.

The American journal of psychiatry·2026
Same journal

2026 Annual Meeting: CEO and Medical Director's Address.

The American journal of psychiatry·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

1.1K

Response to Parikh

David J Miklowitz1, Christopher D Schneck, Boris Birmaher

  • 1From the Department of Psychiatry, University of California, Los Angeles School of Medicine, Los Angeles (Dr. Miklowitz); the Department of Psychiatry, University of Colorado Health Sciences Center, Denver (Dr. Schneck); the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh (Dr. Birmaher); the Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati (Dr. Delbello); and the Department of Psychiatry, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio (Dr. Axelson).

The American Journal of Psychiatry
|March 11, 2015
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.1K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

1.1K
Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.1K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.1K