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Evidence-based strategies to reduce intravenous immunoglobulin-induced headaches
Krisy-Ann Thornby1, Amy Henneman2, Dana A Brown2
1Palm Beach Atlantic University, West Palm Beach, FL, USA krisy_thornby@pba.edu.
The Annals of Pharmacotherapy
|March 12, 2015
Summary
Intravenous immunoglobulin (IVIG) treatment commonly causes headaches or migraines. Various pharmacologic and non-pharmacologic strategies can effectively manage these IVIG-induced headaches, but evidence is limited.
Area of Science:
- Neurology
- Immunology
- Pharmacology
Background:
- Headaches and migraines are frequent adverse effects of intravenous immunoglobulin (IVIG) therapy.
- Managing these symptoms is crucial for patient compliance and treatment success.
Purpose of the Study:
- To review existing literature on pharmacotherapeutic and non-pharmacotherapeutic interventions for IVIG-associated headaches.
- To identify effective strategies for mitigating or treating these common side effects.
Main Methods:
- Systematic literature search of MEDLINE and secondary resources (1946-2015).
- Inclusion of English-language clinical trials and case studies.
- Analysis of 6 clinical studies and 2 case reports.
Main Results:
- Various strategies, including hydration, product switching, slower infusion rates, and medications (analgesics, triptans, etc.), were evaluated.
- Most patients experienced symptom improvement with these interventions.
- Evidence is limited by small sample sizes and lack of direct cause-and-effect data.
Conclusions:
- An individualized treatment plan combining pharmacotherapy and non-pharmacotherapy is recommended.
- Treatment decisions should consider patient condition, IVIG product, migraine history, and prior therapy outcomes.
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