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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

950
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
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Feces Formation and Defecation01:26

Feces Formation and Defecation

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After spending 3 to 10 hours in the large intestine, chyme loses a lot of water and becomes feces, the final product of digestion. Feces consist of undigested dietary fiber such as cellulose, mucus, sloughed-off epithelial cells, and microbes. The descending and sigmoid colon stores feces and uses haustral contractions to dry it out but retains enough water to give it a semi-solid texture.
The mass peristalsis then pushes the feces into the rectum, which stretches the rectal walls to activate...
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Related Experiment Video

Updated: Mar 5, 2026

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Constipation in children: fibre and probiotics.

Merit M Tabbers1, Marc A Benninga

  • 1Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.

BMJ Clinical Evidence
|March 12, 2015
PubMed
Summary

This systematic review examines the effectiveness of fiber and probiotics for treating childhood constipation. Evidence on these interventions for pediatric constipation is synthesized to inform clinical practice.

Area of Science:

  • Pediatric Gastroenterology
  • Evidence-Based Medicine

Background:

  • Childhood constipation affects 1-30% globally, often without clear causes.
  • Chronic constipation can persist into adulthood, impacting quality of life.
  • Withholding behavior and painful defecation are common in children with constipation.

Purpose of the Study:

  • To evaluate the efficacy of fiber supplementation for pediatric chronic constipation.
  • To assess the effectiveness of probiotics in managing childhood constipation.
  • To synthesize current evidence on interventions for childhood constipation.

Main Methods:

  • Systematic review of medical literature up to May 2014.
  • Searched major databases including Medline, Embase, and The Cochrane Library.
  • Included safety alerts from regulatory agencies like the FDA and MHRA.

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Main Results:

  • Twelve studies met the inclusion criteria for the review.
  • GRADE methodology was used to assess the quality of evidence for interventions.
  • Data on the effectiveness and safety of fiber and probiotics were analyzed.

Conclusions:

  • Presents findings on the effectiveness and safety of fiber for childhood constipation.
  • Provides information on the effectiveness and safety of probiotics for pediatric constipation.
  • Informs clinical decision-making regarding the management of chronic constipation in children.