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C1q nephropathy in India: a single-center study.

K V Kanodia1, A V Vanikar, R D Patel

  • 1Department of Pathology, Laboratory Medicine and Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre and Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|March 12, 2015
PubMed
Summary
This summary is machine-generated.

C1q nephropathy (C1qN), a kidney disease with C1q deposits, was found in 0.61% of biopsies. Prognosis depends on histological patterns, not C1q deposits alone.

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Area of Science:

  • Nephrology
  • Immunopathology
  • Renal Pathology

Background:

  • C1q nephropathy (C1qN) is characterized by C1q deposits in glomeruli without systemic lupus erythematosus (SLE).
  • Understanding C1qN's clinical and histological features is crucial for patient management.

Purpose of the Study:

  • To analyze the clinical profile, renal function, and outcomes of patients with C1qN.
  • To determine the prevalence and prognostic factors in C1qN.

Main Methods:

  • Review of 1775 native renal biopsies over three years.
  • Identification of C1qN based on dominant/co-dominant mesangial C1q deposits and absence of SLE.
  • Correlation of clinical presentation, histology, and renal function.

Main Results:

  • C1qN identified in 11 patients (0.61%), predominantly males (8/11), mean age 36.6 years.
  • Nephrotic syndrome was the most common presentation; 72% had hematuria. Mean serum creatinine was 2.78 mg/dL.
  • Mesangial proliferative glomerulonephritis (MePGN) was the most frequent pattern; MePGN showed a better prognosis.

Conclusions:

  • C1qN occurs in 0.61% of renal biopsies with bimodal age distribution.
  • Clinical presentation can be podocytopathy or non-podocytopathy.
  • Prognosis is linked to morphological patterns, not C1q deposits themselves.