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Updated: Apr 16, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
Published on: May 13, 2019
Transcription elongation. Heterogeneous tracking of RNA polymerase and its biological implications
Masahiko Imashimizu1, Nobuo Shimamoto, Taku Oshima
1a Center for Cancer Research; National Cancer Institute; Frederick, MD USA.
Abstract:
Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mechanism of regulation, we introduce the concept of heterogeneity into the previously proposed alternative models of elongation, power stroke and Brownian ratchet. We also discuss molecular origins and physiological significances of the heterogeneity.
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