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Chirality sensing using Ag⁺-thiol coordination polymers.

Qian Zhang1, Yuan Hong, Na Chen

  • 1Department of Chemistry, College of Chemistry and Chemical Engineering, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Xiamen University, Xiamen 361005, China. ybjiang@xmu.edu.cn.

Chemical Communications (Cambridge, England)
|March 14, 2015
PubMed
Summary
This summary is machine-generated.

Chirality sensing is achieved using achiral silver-thiol coordination polymers. These polymers become active for circular dichroism (CD) detection when interacting with chiral molecules like monosaccharides.

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Area of Science:

  • Coordination Chemistry
  • Chiral Sensing
  • Supramolecular Chemistry

Background:

  • Chirality sensing is crucial in various scientific fields.
  • Developing novel sensing platforms for chiral molecules remains a challenge.
  • Achiral materials typically do not exhibit circular dichroism (CD) signals.

Purpose of the Study:

  • To develop a novel chirality sensing platform using achiral coordination polymers.
  • To investigate the CD activity of achiral silver-thiol coordination polymers upon interaction with chiral species.
  • To demonstrate the utility of this platform for monosaccharide detection.

Main Methods:

  • Synthesis of achiral silver(I)-thiol coordination polymers using p-mercaptophenylboronic acid as a ligand.
  • Characterization of the coordination polymers using spectroscopic and crystallographic techniques.
  • Measurement of circular dichroism (CD) spectra upon interaction with various chiral species, including monosaccharides.

Main Results:

  • The achiral silver(I)-thiol coordination polymers exhibit no intrinsic CD activity.
  • Upon binding with chiral species, particularly monosaccharides, the coordination polymers become CD active.
  • The intensity and sign of the CD signal correlate with the chirality and concentration of the analyte.
  • p-Mercaptophenylboronic acid acts as an effective thiol ligand with a binding group for monosaccharides.

Conclusions:

  • Achiral silver-thiol coordination polymers can be effectively utilized as a framework for chirality sensing.
  • The developed system demonstrates a novel approach to induce CD activity in achiral materials for chiral recognition.
  • This method offers a promising strategy for the sensitive detection of chiral molecules, such as monosaccharides.