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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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Engineering Stem Cells for Biomedical Applications.

Perry T Yin1, Edward Han2, Ki-Bum Lee1,3

  • 1Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ, 08854, USA.

Advanced Healthcare Materials
|March 17, 2015
PubMed
Summary
This summary is machine-generated.

Engineered stem cells enhance therapeutic potential through genetic modification and delivery capabilities. This review explores their applications in tissue regeneration, immunodeficiency, and cancer treatment.

Keywords:
engineered stem cellsgene therapymultifunctional nanoparticlesnanomedicineregenerative medicinestem cell therapy

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Stem cells possess inherent therapeutic properties like migration, differentiation, and secretion of factors.
  • Stem cell-based therapies show significant promise for treating diverse human diseases.
  • Enhancing stem cell capabilities through engineering is a key focus for advanced biomedical applications.

Purpose of the Study:

  • To provide a comprehensive overview of engineered stem cells.
  • To detail methods for engineering stem cells and their various forms.
  • To highlight applications in tissue regeneration, immunodeficiency diseases, and cancer.

Main Methods:

  • Genetic modification of stem cells.
  • Utilizing stem cells for gene delivery.
  • Loading stem cells with nanoparticles and small molecule drugs.

Main Results:

  • Engineered stem cells offer enhanced functionalities beyond native capabilities.
  • Demonstrated potential in preclinical and clinical studies for various diseases.
  • Successful application in tissue regeneration and treatment of specific disorders.

Conclusions:

  • Engineered stem cells represent a powerful platform for advanced therapeutic strategies.
  • Further research into cell sources and engineering methods will expand their utility.
  • Significant impact expected in regenerative medicine and treatment of complex diseases like cancer.