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Proposal of a new method for the use of the Rydel-Seiffer tuning fork in the screening of diabetic polyneuropathy. A

R de Simone1, P G Rabitti1, E M De Feo1

  • 1Department of General and Specialist Medicine, I Internal Medicine and Diabetology, A.O.R.N. "A. Cardarelli", Via A. Cardarelli 9, 80131 Napoli, Italy.

Diabetes Research and Clinical Practice
|March 17, 2015
PubMed

Keywords:
Diabetic polyneuropathyRydel–Seiffer methodScreening toolsTuning forkVibration perception threshold assessment

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Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...