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Oral Secondary Syphilis.

Peter N Carbone¹, Gregory G Capra², Brenda L Nelson³

¹Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA. peter.carbone@med.navy.mil.

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Summary

This summary is machine-generated.

Secondary syphilis, a Treponema pallidum infection, causes systemic symptoms and rashes. Diagnosis relies on serologic tests, but condyloma lata requires high suspicion and specific stains for Treponema pallidum.

Keywords:

Condyloma lata Immunohistochemical Secondary syphilis Treponema pallidum

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Area of Science:

Infectious Diseases
Bacteriology
Dermatology

Background:

Secondary syphilis affects about 25% of individuals infected with Treponema pallidum.
It manifests weeks to months after the primary infection's painless chancre.

Observation:

Characterized by systemic symptoms like malaise and fever.
Presents with a maculopapular rash on the trunk, extremities, palms, and soles.
Condyloma lata, raised lesions, may appear at the primary chancre site.

Findings:

Diagnosis primarily uses screening and confirmatory serologic testing.
Histological examination of condyloma lata is often non-specific.
Immunohistochemical stains for T. pallidum are crucial for definitive diagnosis.

Implications:

Highlights the need for clinical suspicion in diagnosing secondary syphilis.
Emphasizes the utility of specific immunohistochemical stains when histology is inconclusive.
Informs diagnostic strategies for Treponema pallidum infections.