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Sine Qua Non: Dentigerous Cyst.

Ryan P Austin1, Brenda L Nelson2

  • 1Department of Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA. ryan.p.austin10.mil@mail.mil.

Head and Neck Pathology
|April 21, 2021
PubMed
Summary
This summary is machine-generated.

Dentigerous cysts, common developmental jaw cysts, are often asymptomatic and found incidentally on dental radiographs. Accurate diagnosis requires correlating classic radiographic and histologic features with clinical context to avoid mischaracterization.

Keywords:
Dental follicleDentigerous cystFollicular cystOdontogenic cystsRadicular cystThird molar

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Area of Science:

  • Oral pathology
  • Developmental biology
  • Odontology

Background:

  • Dentigerous cysts (follicular cysts) are common developmental odontogenic cysts affecting the gnathic bones.
  • They are typically asymptomatic and discovered incidentally on panoramic radiographs.

Observation:

  • Cysts present as unilocular radiolucencies associated with unerupted or impacted tooth crowns.
  • Most frequently occur in the second to third decades, with mandibular third molars being the most common site.
  • Histologically, they feature a fibrous connective tissue wall lined by squamous epithelium, usually without rete ridges.

Findings:

  • Classic radiographic and histologic features aid diagnosis.
  • Differential diagnosis includes other odontogenic cysts and tumors, such as ameloblastoma and odontogenic keratocyst.
  • Inflammation can alter histologic appearance.

Implications:

  • Accurate diagnosis relies on integrating clinical, radiographic, and histologic findings.
  • Misdiagnosis can occur without a complete clinical history, highlighting the importance of context.
  • Understanding these classic features is crucial for effective management of dentigerous cysts.