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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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[Massive localized lymphedema].

M Best1, C Garcia1, S Gonzalez2

  • 1Service de dermatologie, hôpital Carémeau, CHRU de Nîmes, avenue du Pr-Robert-Debré, 30029 Nîmes, France.

Annales De Dermatologie Et De Venereologie
|March 18, 2015
PubMed
Summary
This summary is machine-generated.

Massive localized lymphedema (MLL) is a benign tumor often found in obese adults. Early removal is recommended due to a 13% risk of malignant transformation into angiosarcoma.

Keywords:
Lymphatic edemaLymphœdèmeObesityObésitéSarcomaSarcome

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Massive localized lymphedema (MLL) is a benign soft-tissue tumor.
  • Typically observed in morbidly obese adults as isolated large masses.

Observation:

  • A case of a 39-year-old woman with obesity and multiple MLL lesions is presented.
  • Lesions included a large tumor in the left groin and two smaller ones on the thighs.

Findings:

  • MLL is a benign neoplasm.
  • A significant risk (13%) of malignant degeneration into angiosarcoma exists.
  • Prolonged lymphatic obstruction due to excess adipose tissue is the probable cause.

Implications:

  • Surgical removal of MLL is advised to prevent malignant transformation.
  • Understanding the link between obesity and MLL is crucial for patient management.
  • Further research into MLL pathogenesis and prevention strategies is warranted.