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Biofabricated constructs as tissue models: a short review.

Pedro F Costa1

  • 1Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 30, 81675, Munich, Germany, pedro.costa@tum.de.

Journal of Materials Science. Materials in Medicine
|March 18, 2015
PubMed
Summary

Biofabrication technologies create increasingly sophisticated tissue models. Overcoming vascularization challenges is key to replicating complex organs for research and development.

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Biofabrication offers reliable models for studying cell and tissue development.
  • Increasing construct complexity enhances mimicry of native tissues and organs.
  • High automation enables large-scale in vitro and in vivo studies.

Purpose of the Study:

  • To review current biofabrication technologies and methodologies.
  • To discuss their potential applications in tissue engineering.
  • To highlight challenges, particularly vascularization, in creating complex constructs.

Main Methods:

  • Review of existing biofabrication technologies (e.g., 3D printing, bioprinting).
  • Analysis of methods for assembling multiple cell types and materials.
  • Examination of automation in high-throughput screening.

Main Results:

  • Biofabrication enables precise, multi-dimensional cell/tissue construction.
  • Technologies can assemble diverse cells and materials for tissue mimicry.
  • Significant progress has been made, but complex organoid generation remains a challenge.

Conclusions:

  • Biofabrication is rapidly advancing towards complex organoid models.
  • Generating intricate vascular networks is a critical hurdle.
  • Further development is needed to fully realize the potential of biofabricated organs.