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Area of Science:

  • Dermatology
  • Immunodermatology
  • Pathology

Background:

  • Pemphigus vulgaris is an intraepidermal blistering disease.
  • It typically manifests as flaccid bullae or erosions.

Observation:

  • A patient presented with atypical pemphigus vulgaris.
  • Clinical features included tense bullae with pus, targetoid lesions, and desquamation.
  • These signs initially mimicked toxic epidermal necrolysis.

Findings:

  • The patient's presentation deviated from typical pemphigus vulgaris morphology.
  • Unusual findings included tense bullae, pus layering, annular configurations, and diffuse desquamation.
  • Differential diagnosis was challenging due to these atypical features.

Implications:

  • Recognizing unusual presentations of pemphigus vulgaris is crucial.
  • Morphological variations can complicate diagnosis and necessitate broader differential considerations.
  • This case underscores the spectrum of pemphigus vulgaris and its mimics.