Related Experiment Video

Updated: Apr 16, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

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Gout

Martin Underwood1

  • 1Warwick Medical School, University of Warwick, Coventry, UK.

BMJ Clinical Evidence
|March 20, 2015
PubMed

Insights

This systematic review evaluates treatments for acute gout and xanthine oxidase inhibitors for gout prevention. It found 21 studies on colchicine, corticosteroids, and NSAIDs, assessing their effectiveness and safety.

Area of Science:

  • Rheumatology
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Gout is a common condition affecting 5% of men and 1% of women.
  • Up to 80% of gout patients experience recurrent attacks within three years.

Purpose of the Study:

  • To systematically review the effects of treatments for acute gout.
  • To evaluate the efficacy of xanthine oxidase inhibitors in preventing recurrent gout episodes.

Main Methods:

  • Systematic review of studies up to September 2013.
  • Searches conducted in Medline, Embase, and The Cochrane Library.
  • Inclusion of harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Twenty-one studies met the inclusion criteria for the review.
  • GRADE evaluation was performed to assess the quality of evidence for interventions.

Conclusions:

  • The review presents data on the effectiveness and safety of key gout interventions.
  • Interventions discussed include colchicine, corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and xanthine oxidase inhibitors.
Abstract

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