Orbital tumor revealing a systemic sarcoidosis

Area of Science:

• Ophthalmology
• Rheumatology
• Pathology

Background:

• Sarcoidosis commonly affects the eyes, with uveitis being the most frequent manifestation.
• Ocular involvement occurs in about 25% of sarcoidosis patients.
• Orbital sarcoidosis is an uncommon but significant finding.

Observation:

• A 65-year-old woman presented with unilateral eyelid swelling and eye redness.
• Orbital imaging revealed a mass in the inferior right orbital soft tissue.
• Biopsy confirmed nodular, noncaseating granulomas, indicative of sarcoidosis.

Findings:

• The patient exhibited systemic sarcoidosis with hilar and mediastinal lymphadenopathy on CT scan.
• The orbital mass was surgically treated, followed by systemic prednisone.
• The patient showed a positive response to treatment.

Implications:

• Orbital sarcoidosis should be considered in the differential diagnosis of orbital tumors, especially in elderly patients.
• Comprehensive systemic evaluation is essential for diagnosing sarcoidosis.
• Prompt and appropriate therapy, including corticosteroids, can lead to favorable outcomes.