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Co-processing of hydroxypropyl methylcellulose (HPMC) for improved aqueous dispersibility
Payal Sharma1, Sameer R Modi1, Arvind K Bansal1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Punjab 160062, India.
International Journal of Pharmaceutics
|March 23, 2015
Summary
Spray drying co-processing of hydroxypropyl methylcellulose (HPMC) with excipients significantly improves its aqueous dispersibility. This method enhances wetting and dissolution, overcoming the poor dispersion issues of native HPMC.
Area of Science:
- Materials Science
- Pharmaceutical Technology
Background:
- Hydroxypropyl methylcellulose (HPMC) is a common film coating polymer with poor aqueous dispersibility due to rapid hydration and gel formation.
- This poor dispersibility leads to lump formation and incomplete dissolution, hindering its application.
Purpose of the Study:
- To improve the aqueous dispersibility of HPMC using a spray drying co-processing approach.
- To investigate the mechanisms behind the enhanced dispersibility through various analytical techniques.
Main Methods:
- Co-processing of HPMC with excipients (lactose, sodium chloride) via spray drying.
- Evaluation of dispersion behavior through dissolution time measurements.
- Mechanistic studies using contact angle, CLSM, TEM, and STEM.
Main Results:
- Native HPMC showed poor dispersion, forming lumps and taking 40 minutes to dissolve.
- HPMC co-processed with lactose and sodium chloride demonstrated improved dispersibility, dissolving completely within 20 minutes.
- Co-processed products exhibited enhanced wetting and erodible gel structures, with improved sub-particulate properties.
Conclusions:
- Spray drying co-processing effectively enhances HPMC dispersibility by modifying its sub-particulate characteristics.
- The study provides insights into excipient selection for optimizing HPMC dispersion and film properties.
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