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Related Experiment Video

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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Multiscale assembly for tissue engineering and regenerative medicine.

Sinan Guven1, Pu Chen1, Fatih Inci1

  • 1Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA 94304, USA.

Trends in Biotechnology
|March 23, 2015
PubMed
Summary

This review explores bioengineering strategies for creating tissue-mimicking grafts by assembling building blocks from molecules to millimeter scales. It highlights techniques for bottom-up tissue engineering and assembly mechanisms for diverse tissue structures.

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Area of Science:

  • Bioengineering
  • Materials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Advancements in cell biology and materials science drive innovations in bioengineering.
  • Tissue-mimicking grafts are crucial for clinical and pharmaceutical applications.
  • Controlling the cellular microenvironment is key to developing functional engineered tissues.

Purpose of the Study:

  • To review methods for assembling multiscale building blocks in tissue engineering.
  • To provide an overview of bottom-up tissue engineering techniques.
  • To discuss assembly mechanisms for creating micro-to-macro scale tissue structures.

Main Methods:

  • Assembly of biomolecular components, cells, spheroids, and microgels.
  • Utilizing self-assembly and guided assembly mechanisms.
  • Focus on bottom-up approaches for tissue construction.

Main Results:

  • Demonstrated techniques for assembling building blocks across multiple scales (biomolecular to millimeter).
  • Provided a comprehensive overview of current bottom-up tissue engineering strategies.
  • Identified key driving mechanisms for controlled tissue assembly.

Conclusions:

  • Bioengineering approaches integrating cell biology and materials science enable the creation of functional, native-like tissue grafts.
  • Multiscale assembly strategies are critical for precise control over the cellular microenvironment.
  • Bottom-up tissue engineering offers promising avenues for developing advanced therapeutic and research tools.