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Updated: Apr 15, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
Optimal timing of valve replacement in asymptomatic severe aortic stenosis
Insights
Risk stratifying asymptomatic severe aortic stenosis (AS) is crucial. New methods beyond traditional parameters are vital for accurately assessing AS severity and patient risk.
Area of Science:
- Cardiology
- Cardiovascular Medicine
Background:
- Asymptomatic severe aortic stenosis (AS) patients are a heterogeneous group with varying risks.
- Degenerative AS involves valve stricture, arterial stiffness, and varied left ventricular responses.
Purpose of the Study:
- To highlight the importance of risk stratification in asymptomatic severe AS.
- To advocate for comprehensive AS severity assessment using both conventional and novel methods.
Main Methods:
- Review of traditional parameters for AS assessment.
- Inclusion of novel measures like energy loss index and valvulo-arterial impedance.
- Consideration of natriuretic peptide levels and global longitudinal strain imaging.
- Evaluation of exercise stress testing and echocardiography for symptomatic assessment.
Main Results:
- Traditional parameters alone may not fully capture AS severity and patient risk.
- Newer indices provide additional insights into valvular and ventricular load.
- Secondary parameters offer information on left ventricular systolic function.
Conclusions:
- Accurate risk stratification is essential for managing asymptomatic severe AS.
- Integrating advanced assessment methods improves the understanding of AS severity and patient prognosis.
- A multi-faceted approach is recommended for optimal patient management.
Abstract:
Patients with asymptomatic severe aortic stenosis (AS) constitute a heterogeneous group which includes not only certain cases who are at high risk of sudden death and valve-related heart failure, but also those at low risk for these events. Degenerative AS, which includes a majority of patients with AS, is characterized by stricture of the valve, increased arterial stiffness, and diverse left ventricular response to the valvular plus arterial vascular load. In addition to using traditional primary parameters, the severity of AS and the total left ventricular load should be assessed using new measures such as energy loss index and valvulo-arterial impedance. Natriuretic peptide levels and global longitudinal strain imaging may also be used as secondary parameters to obtain information about left ventricular systolic function, although these parameters do not correlate with the severity of AS. Exercise stress testing and exercise echocardiography are also beneficial when assessing the patient if they are symptomatic, and for determining valvular and left ventricular contractile reserves. The aim of this review was to emphasize the importance of risk stratifications in asymptomatic severe AS cases, and to assess the severity of AS using not only conventional methods but also new methods on which much emphasis has been placed during recent years.
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