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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Cell Specific Gene Expression01:58

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Related Experiment Video

Updated: Apr 15, 2026

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
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Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

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Epigenetic modifications and long noncoding RNAs influence pancreas development and function.

Luis Arnes1, Lori Sussel1

  • 1Department of Genetics and Development, Columbia University, New York, NY, USA.

Trends in Genetics : TIG
|March 28, 2015
PubMed
Summary
This summary is machine-generated.

Loss of insulin-producing beta cells causes diabetes. Epigenetic modifications and long noncoding RNAs (lncRNAs) are key to pancreas development and beta cell function, offering new diabetes treatment strategies.

Keywords:
epigeneticisletlong noncoding RNAspancreasβ cells

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Area of Science:

  • Endocrinology and Metabolism
  • Molecular Biology
  • Developmental Biology

Background:

  • Insulin-producing beta cells in the pancreas are crucial for glucose homeostasis.
  • Beta cell loss or dysfunction leads to diabetes mellitus.
  • Understanding beta cell regulation is vital for diabetes treatment.

Purpose of the Study:

  • To investigate the role of epigenetic modifications and long noncoding RNAs (lncRNAs) in pancreas development and beta cell function.
  • To identify novel regulatory mechanisms in beta cells.
  • To explore therapeutic strategies for beta cell restoration in diabetes.

Main Methods:

  • Advanced cell purification techniques.
  • Next-generation sequencing technologies.
  • Novel molecular and genetic tools.

Main Results:

  • Epigenetic modifications and lncRNAs are integral to transcriptional regulation in the pancreas.
  • These mechanisms play a significant role in pancreas development and beta cell function.
  • A new layer of gene regulation in beta cells has been uncovered.

Conclusions:

  • Epigenetic modifications and lncRNAs are critical regulators of beta cell function.
  • These findings reveal potential therapeutic targets for diabetes.
  • Exploiting these regulatory layers may enhance beta cell repair and restoration for diabetes treatment.