Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?

Journal of neuroinflammation·2026

Same author

The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk.

Cellular and molecular neurobiology·2026

Same author

Folate Receptor Alpha (FRα) and the Developing Brain: From Molecular Function to Neurodevelopmental Outcomes.

Molecular neurobiology·2026

Same author

Three-dimensional approaches to measuring primary cilia in hippocampal neurons: A comparative analysis.

Journal of neuropathology and experimental neurology·2026

Same author

Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis.

The Journal of international medical research·2026

Same author

NFKBIZ mediates neuroprotection and maintains blood-brain barrier integrity in cerebral ischemia/reperfusion via STAT3-regulated Nrf2/ARE signaling.

Experimental neurology·2026

Same journal

Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index.

Frontiers in neuroscience·2026

Same journal

Neuroprotective effects of paederoside against mitochondrial dysfunction in rotenone-induced cell models of Parkinson's disease.

Frontiers in neuroscience·2026

Same journal

Covariance-based analysis of spindle-band EEG during declarative and non-declarative odor cueing in sleep.

Frontiers in neuroscience·2026

Same journal

Correction: Physiological determinants of cortical P100 responses in pattern visual evoked potentials: a scoping review.

Frontiers in neuroscience·2026

Same journal

Transcranial magnetic stimulation and motor overflow: a systematic review in neurological disorders.

Frontiers in neuroscience·2026

Same journal

Editorial: Advancing neurodegenerative disease biomarkers: the role of neuroimaging in TDP-43 and tau proteinopathies.

Frontiers in neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

Published on: June 16, 2023

Transcriptomal changes and functional annotation of the developing non-human primate choroid plexus.

C Joakim Ek¹, Peter Nathanielsz², Cun Li²

¹Department of Physiology, Institute for Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy Gothenburg, Sweden.

Frontiers in Neuroscience

|March 28, 2015

Summary

This summary is machine-generated.

The choroid plexus, crucial for brain development, shows dynamic gene expression changes in fetal baboons. This suggests a more active role earlier in development than previously understood.

Keywords:

RNAseq baboon choroid plexus development fetus non-human primate transcriptome

More Related Videos

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain

A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain

Published on: November 14, 2012

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

Published on: June 16, 2023

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain

A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain

Published on: November 14, 2012

Area of Science:

Developmental Neuroscience
Genomics
Comparative Biology

Background:

Choroid plexuses produce cerebrospinal fluid and influence brain development.
Their precise developmental roles, especially in humans, remain unclear.
Rodent models have limitations due to differing brain maturation timelines.

Purpose of the Study:

To investigate choroid plexus development using a non-human primate model.
To analyze transcriptomic changes during fetal development.
To understand the choroid plexus's role in shaping brain maturation.

Main Methods:

Collected baboon fetal choroid plexus across three gestational ages.
Performed next-generation sequencing to determine transcriptomes.
Utilized Ingenuity Pathway Analysis for functional annotation.

Main Results:

Transcript numbers decreased with development; most transcripts were down-regulated.
Functional annotation revealed changes in gene expression, cardiovascular, nervous system development, and molecular transport.
Age-dependent gene regulation was observed, indicating complex early developmental roles.

Conclusions:

The baboon choroid plexus exhibits significant transcriptomic shifts during fetal development.
Findings suggest a more complex and active choroid plexus earlier in development.
The choroid plexus actively participates in shaping brain development through secreted factors.