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Updated: Apr 15, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Temporal trends in chorioamnionitis by maternal race/ethnicity and gestational age (1995-2010)
Michael J Fassett1, Deborah A Wing2, Darios Getahun3
1Division of Maternal-Fetal Medicine, Department of Obstetrics-Gynecology, West Los Angeles Kaiser Permanente Southern California Medical Group, Los Angeles, CA 90034, USA.
Abstract:
Objective. To characterize trends in chorioamnionitis (CAM) by maternal race/ethnicity and gestational age. Study Design. We examined trends in CAM from 1995-2010 among singleton births in all Kaiser Permanente Southern California hospitals (n = 471,821). Data were extracted from Perinatal Service System and clinical utilization records. Gestational age- and race/ethnicity-specific biannual diagnosis rates were estimated using the Poisson regression after adjusting for potential confounding factors. Results. Overall diagnosis rates of CAM increased from 2.7% in 1995-1996 to 6.0% in 2009-2010 with a relative increase of 126% (95% confidence intervals [CI] 113%-149%). From 1995-1996 to 2009-2010, CAM increased among the Whites (1.8% to 4.3%, P-value for trend <.001), Blacks (2.2% to 3.7%, P-value for trend <.001), Hispanics (2.4% to 5.8%, P-value for trend <.001), and Asian/Pacific Islanders (3.6% to 9.0%, P-value for trend <.001). The adjusted relative percentage change in CAM from 1995-1996 to 2009-2010 was for Whites [preterm 21% (9%-78%), term 138% (108%-173%)], for Blacks [preterm 24% (-9%-81%), term 62% (30%-101%)], for Hispanics [preterm 31% (3%-66%), term 135% (114%-159%)], and for Asian/Pacific Islanders [preterm 44% (9%-127%), term 145% (109%-188%)]. Conclusion. The findings suggest that CAM diagnosis rate has increased for all race/ethnic groups. This increase is primarily due to increased diagnosis at term gestation.
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