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[Association between rs1079595 polymorphisms in the DRD2 gene and the distractibility based the temperament in
Enhebayaer Enhebayaer1, Yu-Ling Li, Hong-Yan Guan
1Institute of Life Science and Technology, Inner Mongolia Normal University, Huhhot 010022, China. liyuling137@163.com.
Objective:
To study the association between rs1079595 polymorphisms in the DRD2 gene and the distractibility in school-age children.
Methods:
The genotyping at rs1079595 was performed and the distractibility was measured based on the temperament questionnaire in 120 8-12 years old school-age children in order to analyze the effects of the rs1079595 polymorphism and its interaction with the gender, age and delivery mode on the distractibility.
Results:
There was an association between the distractibility and rs1079595 polymorphisms. The distractibility score in children with GG/GT genotypes was significantly higher than in children with the TT genotype (4.3 ± 0.6 vs 4.0 ± 0.7; P<0.05). The interaction between rs1079595 polymorphisms and the delivery mode produced an effect on the distractibility. The normal delivery children with T alleles were associated with a low distractibility (OR=0.037, P<0.01).
Conclusions:
The distractibility based the temperament might be influenced by the rs1079595 polymorphism and its interaction with the delivery mode in school-age children.
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