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[Skin and mucous membrane microbiocenosis during atopic dermatitis in children]

M N Repetskaia, Iu N Maslov, E V Shaĭdullina

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |March 31, 2015
    PubMed

    Insights

    Children with atopic dermatitis show altered skin, oropharynx, and intestine microbiomes. Early detection of oropharyngeal and intestinal dysbiosis is crucial for managing this condition.

    Area of Science:

    • Microbiology
    • Dermatology
    • Pediatrics

    Context:

    • Atopic dermatitis (AD) in children is associated with significant alterations in microbial communities.
    • Understanding the interplay between skin, oropharyngeal, and intestinal microbiomes is vital for AD pathogenesis.
    • Previous research has indicated dysbiosis in AD, but comprehensive analysis across multiple body sites is needed.

    Purpose:

    • To investigate the microbial landscape of the skin, oropharynx, and intestine in children with atopic dermatitis.
    • To determine the interactions between these distinct microbial communities.
    • To identify specific microbial changes associated with atopic dermatitis in pediatric patients.

    Summary:

    • A study of 60 children with atopic dermatitis revealed significant quantitative and qualitative changes in skin, oropharyngeal, and intestinal microbiocenoses.
    • Staphylococcus aureus colonization was more frequent on the skin, with Gram-positive bacteria dominating the oropharynx.
    • A direct correlation was observed between skin and oropharyngeal microflora, and all participants exhibited intestinal dysbiosis.

    Impact:

    • Findings suggest incorporating oropharyngeal wash analysis into routine examinations for atopic dermatitis patients.
    • Recommendations include screening all children with atopic dermatitis for intestinal dysbiosis.
    • This research highlights the importance of a holistic approach to managing the microbiome in pediatric atopic dermatitis.
    Abstract

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