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Image quantification with a large area multiwire proportional chamber positron camera (MUP-PET)
S R Cherry1, P K Marsden, R J Ott
1Joint Department of Physics, Royal Marsden Hospital, Sutton, UK.
European Journal of Nuclear Medicine
|January 1, 1989
Summary
This study evaluates a multi wire proportional chamber positron camera system for nuclear medicine. The system demonstrates accurate quantification and image reconstruction for clinical investigations.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Positron Emission Tomography (PET)
Background:
- Evaluation of a large area multi wire proportional chamber positron camera system.
- Utilizes isotopes from generators (68Ga) and cyclotrons (18F, 124I, 64Cu, 81Rb).
Purpose of the Study:
- Assess the performance of the MUP-PET system for clinical nuclear medicine.
- Focus on quantification accuracy and attenuation correction for large area detectors.
Main Methods:
- Image reconstruction using a fully 3D algorithm.
- Development of an attenuation correction scheme.
- Investigation of scattered and accidental events.
- Calculation of dead time correction factors.
Main Results:
- Equal resolution in all three orthogonal directions.
- Axial field of view (15 cm) sufficient for whole brain coverage.
- Scattered and accidental events contribute uniform background.
- Strong linear correlation (r=0.998) between count density and isotope concentration post-correction.
Conclusions:
- The MUP-PET system shows potential for accurate quantification in clinical nuclear medicine.
- Developed methods for attenuation and dead time correction are effective.
- The system's performance supports extension to clinical studies.