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Updated: Apr 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Glatiramer acetate-induced lobular panniculitis and skin necrosis
Casey E Watkins1, John Litchfield, George Youngberg
1Quillen College of Medicine, East Tennessee State University, PO Box 70580, Johnson City, TN 37614, USA. watkince@goldmail.etsu.edu.
Abstract:
Glatiramer acetate (GA) is a drug that commonly is used for the treatment of relapsing-remitting multiple sclerosis (RRMS). Although it typically is known as a safe and effective therapy, a number of adverse effects associated with GA have been reported in the literature. Local injection-site reactions (LISRs) and mild systemic symptoms are among the most commonly described adverse effects. A review of the literature revealed limited reports of panniculitis as an adverse effect of GA injection and even fewer describing associated skin necrosis. We report a case of GA-induced panniculitis and skin necrosis and discuss the occurrence of panniculitis, necrosis, and lipoatrophy following GA injections.
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