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Microencapsulation using poly(L-lactic acid). I: Microcapsule properties affected by the preparative technique.

R Jalil1, J R Nixon

  • 1Chelsea Department of Pharmacy, King's College London.

Journal of Microencapsulation
|October 1, 1989
PubMed
Summary
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Poly (L-lactic acid) microcapsules prepared via oil-in-water (o/w) and water-in-oil (w/o) emulsion techniques showed distinct properties. The w/o system yielded higher phenobarbitone (PB) loading and porous microcapsules compared to the o/w system.

Area of Science:

  • Polymer science and drug delivery systems.
  • Materials science and microencapsulation techniques.

Background:

  • Poly (L-lactic acid) (L-PLA) is a biodegradable polymer frequently used for microencapsulation.
  • Phenobarbitone (PB) is a model drug used to evaluate drug loading and release characteristics.
  • Emulsification and solvent evaporation are common techniques for microcapsule preparation.

Purpose of the Study:

  • To investigate the effect of oil-in-water (o/w) and water-in-oil (w/o) emulsion systems on poly (L-lactic acid) microcapsule properties.
  • To compare phenobarbitone (PB) loading and microcapsule morphology prepared by different techniques.

Main Methods:

  • Microcapsules were prepared using poly (L-lactic acid) (L-PLA) and phenobarbitone (PB) via emulsification and solvent evaporation.
  • Two emulsion systems were employed: o/w using dichloromethane and w/o using acetonitrile and light liquid paraffin.

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  • Microcapsule properties, including drug loading and surface morphology, were analyzed.

    • Main Results:

    • The w/o system resulted in significantly higher PB loading within the microcapsules compared to the o/w system.
    • Microcapsules prepared by the w/o technique exhibited a highly porous surface with embedded PB crystals.
    • Microcapsules from the o/w system were smaller and displayed a smoother, less porous surface.

    Conclusions:

    • The choice of emulsion system critically influences the characteristics of L-PLA microcapsules and their drug-loading efficiency.
    • The w/o system is more effective for achieving high drug loading and creating porous microstructures.
    • The preparative technique significantly impacts microcapsule morphology and surface properties.