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Membranoproliferative glomerulonephritis and Pott's disease
Rapur Ram1, Peddi Sandeep1, Annapindi Venkatasatya Surya Naga Sridhar1
1Department of Nephrology , Sri Venkateswara Institute of Medical Sciences , Tirupati 500083 , India.
Clinical Kidney Journal
|April 9, 2015
Summary
Tuberculosis can cause kidney disease, specifically membrano-proliferative glomerulonephritis. Early diagnosis and treatment with anti-tuberculous medication improved renal function in a patient with this rare condition.
Area of Science:
- Nephrology
- Infectious Diseases
- Pathology
Background:
- Glomerular lesions of the kidney caused by tuberculosis are rarely reported.
- A 48-year-old male presented with edema and renal impairment, including proteinuria and normal kidney size.
Purpose of the Study:
- To investigate the link between tuberculosis and kidney glomerular lesions.
- To report a case of membrano-proliferative glomerulonephritis secondary to tuberculosis.
Main Methods:
- Renal biopsy with light microscopy and immunofluorescence.
- Magnetic Resonance Imaging (MRI) of the spine.
- Aspiration and analysis of paravertebral abscess fluid for Mycobacterium tuberculosis.
Main Results:
- Renal biopsy confirmed membrano-proliferative glomerulonephritis.
- MRI revealed a paravertebral abscess at D11-D12.
- Aspiration confirmed Mycobacterium tuberculosis in the abscess.
- After 8 weeks of anti-tuberculous therapy, serum creatinine improved to 1.5 mg/dL and 24-hour urine protein decreased to 250 mg.
Conclusions:
- Tuberculosis can manifest with glomerular kidney disease.
- Prompt diagnosis and treatment of tuberculosis are crucial for renal recovery.
- This case highlights the importance of considering tuberculosis in patients with unexplained glomerulonephritis.
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