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Protein motions and dynamic effects in enzyme catalysis

Louis Y P Luk1, E Joel Loveridge1, Rudolf K Allemann1

  • 1School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK. allemannrk@cardiff.ac.uk.

Physical Chemistry Chemical Physics : PCCP
|April 10, 2015
PubMed
Summary

Protein dynamics can hinder enzyme catalysis, suggesting evolutionary selection against such motions in dihydrofolate reductase (DHFR). Fine-tuning protein movements is crucial for optimal enzyme function.

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