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Published on: July 11, 2013
RISK OF RETINAL VEIN OCCLUSION IN PATIENTS WITH PSORIASIS: A Population-Based Cohort Study
Yung-Chang Yen1, Shih-Feng Weng, Feng-Jie Lai
1*Department of Ophthalmology, Chi Mei Medical Center, Liou-Ying, Tainan City, Taiwan; †Department of Nursing, Min Hwei College of Health Care Management, Tainan City, Taiwan; ‡Department of Medical Research, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; §Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Ren De District, Tainan City, Taiwan; ¶Department of Dermatology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; **Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan; ††Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; and ‡‡Department of Otolaryngology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan.
Purpose:
To investigate the risk of developing retinal vein occlusion (RVO) in patients with psoriasis.
Methods:
In this retrospective population-based cohort study, 30,198 patients with psoriasis (Psoriasis((+)) group) and 30,198 controls without psoriasis (Psoriasis((−)) group) between 2001 and 2006 from the Taiwan National Health Insurance Research Database were selected.
Results:
The incidence of RVO was 1.46 times higher in the Psoriasis((+)) group than in the Psoriasis((−)) group (3.61 vs. 2.47/10,000 person-years) (adjusted hazard ratio = 1.50; 95% confidence interval = 1.07-2.10) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO (adjusted hazard ratio: 11.9 for patients 65 years or older vs. 1.00 for those 0-49 years old). In the 65 years or older Psoriasis((+)) group, the incidence of developing RVO was 1.97 times higher (95% confidence interval = 1.19-3.26) than in the 65 years or older Psoriasis((−)) group. In Psoriasis((+)) women, the incidence of developing RVO was 1.82 times higher (95% = 1.05-3.14) than in Psoriasis((−)) women. For the subgroup with comorbid hypertension, the incidence of developing RVO was 2.07 times higher (95% confidence interval = 1.22-3.50) in the Psoriasis((+)) group than in the Psoriasis((−)) group.
Conclusion:
Psoriasis was significantly associated with a higher risk of developing RVO.
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