Related Experiment Video
Updated: Apr 15, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Inner and outer retinal thickness mapping of nonproliferative diabetic retinopathy by spectral-domain optical
Background And Objective:
To report inner retinal thickness (IRT), outer retinal thickness (ORT), and total retinal thickness (TRT) mapping of nonproliferative diabetic retinopathy (DR).
Patients And Methods:
Spectral-domain optical coherence tomography (SD-OCT) images were obtained in 31 study participants with nonproliferative DR. Semi-automated software generated IRT, ORT, and TRT maps. IRT, ORT, and TRT in each macular subfield were compared between groups with and without increased central subfield thickness.
Results:
There were statistically significant differences in IRT, ORT, and TRT between groups (P < .007). In participants with nonproliferative DR with increased central subfield thickness, TRT was significantly increased in parafoveal and perifoveal inferior subfields (P < .001). In these subfields, both IRT and ORT were significantly increased (P < .007) compared to those in participants without increased central subfield thickness.
Conclusion:
Mapping of inner and outer retinal thickness shows promise for monitoring depth-specific thickness alterations by macular subfields due to DR.
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