Related Experiment Video
Updated: Apr 15, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Exertional heat illness: emerging concepts and advances in prehospital care
Riana R Pryor1, Ronald N Roth2, Joe Suyama2
11University of Connecticut,Department of Kinesiology,Storrs,Connecticut USA.
Abstract:
Exertional heat illness is a classification of disease with clinical presentations that are not always diagnosed easily. Exertional heat stroke is a significant cause of death in competitive sports, and the increasing popularity of marathons races and ultra-endurance competitions will make treating many heat illnesses more common for Emergency Medical Services (EMS) providers. Although evidence is available primarily from case series and healthy volunteer studies, the consensus for treating exertional heat illness, coupled with altered mental status, is whole body rapid cooling. Cold or ice water immersion remains the most effective treatment to achieve this goal. External thermometry is unreliable in the context of heat stress and direct internal temperature measurement by rectal or esophageal probes must be used when diagnosing heat illness and during cooling. With rapid recognition and implementation of effective cooling, most patients suffering from exertional heat stroke will recover quickly and can be discharged home with instructions to rest and to avoid heat stress and exercise for a minimum of 48 hours; although, further research pertaining to return to activity is warranted.
Related Concept Videos
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Decreased Body Temperature
Increased Body Temperature
Homeostatic Imbalances in Body Temperature
Factors Affecting Body Temperature
Factors may include:
Cardiopulmonary Resuscitation IV: Pharmacological Management

