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Updated: Apr 15, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Chordoma and chondrosarcoma.

Jamie J Van Gompel¹, Jeffrey R Janus²

¹Departments of Neurosurgery and Otolaryngology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA.

Otolaryngologic Clinics of North America

|April 13, 2015

Summary

This summary is machine-generated.

Chordoma and chondrosarcoma are challenging skull base tumors. Surgical resection is key, with adjuvant therapies like radiation therapy and stereotactic radiosurgery offering options for management and local progression.

Keywords:

Chondrosarcoma Chordoma Outcome Proton beam Surgery

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Area of Science:

Neurosurgery
Oncology
Radiology

Background:

Chordoma and chondrosarcoma are distinct central skull base pathologies.
These tumors present significant management challenges.
Surgical resection is the primary treatment modality.

Purpose of the Study:

To review the current understanding and management strategies for chordoma and chondrosarcoma.
To highlight the role of surgical resection and adjuvant therapies.

Main Methods:

Review of existing literature on chordoma and chondrosarcoma management.
Analysis of treatment outcomes based on completeness of resection.
Evaluation of adjuvant therapy roles, including radiation and radiosurgery.

Main Results:

Outcomes for chordoma and chondrosarcoma are heavily influenced by the extent of surgical resection.
Adjuvant therapy, particularly radiation therapy, is frequently used postoperatively.
Stereotactic radiosurgery is utilized for primary treatment or managing local recurrence.

Conclusions:

Complete surgical resection is critical for favorable outcomes in chordoma and chondrosarcoma.
The role of adjuvant therapies requires careful consideration.
Multimodal treatment approaches are often necessary for these complex skull base tumors.