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Updated: Apr 15, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Accepted but unacceptable: peripheral IV catheter failure.
Robert E Helm1, Jeffrey D Klausner, John D Klemperer
1Portsmouth Regional Hospital, Department of Cardiothoracic and Vascular Surgery, Portsmouth, New Hampshire (Dr Helm); University of California, Division of Infectious Diseases, Los Angeles, California (Dr Klausner and Ms Huang); and Eastern Maine Medical Center, Division of Cardiovascular Surgery, Bangor, Maine (Dr Klemperer). Robert E. Helm, MD, is a cardiothoracic surgeon in the Department of Cardiothoracic and Vascular Surgery at the Portsmouth Regional Hospital in Portsmouth, New Hampshire. Jeffrey D. Klausner, MD, MPH, is a professor of medicine in the Division of Infectious Diseases at the University of California, Los Angeles. John D. Klemperer, MD, is a cardiothoracic surgeon in the Division of Cardiovascular Surgery at the Eastern Maine Medical Center in Bangor, Maine. Lori M. Flint, BSN, RN, CCRN, is a critical care nurse. Emily Huang, BA, is a research assistant in the Division of Infectious Diseases at the University of California, Los Angeles.
Peripheral intravenous (IV) catheter insertion is common but has a high failure rate (35-50%). Understanding the causes of peripheral IV failure can lead to significant improvements in patient care and healthcare efficiency.
Area of Science:
- Medical procedures
- Vascular access
- Patient safety
Background:
- Peripheral intravenous (IV) catheter insertion is the most frequent invasive hospital procedure globally.
- Current peripheral IV catheter failure rates range from 35% to 50%, indicating significant room for improvement.
- Catheter failure incurs substantial costs for patients, healthcare providers, and the overall health system.
Purpose of the Study:
- To analyze the underlying mechanisms contributing to the high failure rate of peripheral IV catheters.
- To identify opportunities for enhancing the success and reliability of peripheral IV insertions.
Main Methods:
- Review of existing literature on peripheral IV catheter insertion complications.
- Analysis of data pertaining to peripheral IV catheter failure rates.
- Examination of factors contributing to procedural failure.
Main Results:
- Peripheral IV catheter insertion exhibits a high overall failure rate, impacting patient outcomes and healthcare resources.
- Despite technological advancements, significant challenges persist in achieving consistent success with peripheral IV placement.
- Specific mechanisms contributing to catheter failure have been identified, highlighting areas for intervention.
Conclusions:
- Persistent high failure rates in peripheral IV catheterization present a critical issue in healthcare delivery.
- Further investigation into the identified failure mechanisms is crucial for developing targeted improvement strategies.
- Optimizing peripheral IV insertion techniques and management can reduce complications and associated costs.
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