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Related Concept Videos

Thermosensation01:43

Thermosensation

35.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

13.7K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
13.7K
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

11.2K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
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Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

15.6K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
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Related Experiment Video

Updated: Apr 15, 2026

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.5K

[The progress of TRP channels in structural studies].

Di-Jing Shi, Ke-Wei Wang

    Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
    |April 16, 2015
    PubMed
    Summary

    Structural studies of Transient Receptor Potential (TRP) channels have advanced significantly. This review summarizes recent progress in understanding TRP channel structures, assembly, and gating mechanisms.

    Area of Science:

    • Molecular Biology
    • Biophysics
    • Structural Biology

    Background:

    • Transient Receptor Potential (TRP) channels are crucial nonselective cation channels involved in sensing environmental stimuli.
    • Significant advancements in structural biology have been made over the last decade for TRP channels.
    • Understanding TRP channel structure is key to elucidating their function in cellular processes.

    Purpose of the Study:

    • To review the current structural knowledge of Transient Receptor Potential (TRP) channels.
    • To highlight progress in TRP channel structural studies, particularly over the last two years.
    • To provide insights into TRP channel gating, assembly, and regulation based on structural data.

    Main Methods:

    • Compilation and analysis of published structural data for TRP channels.

    More Related Videos

    Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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    Purification of Endogenous Drosophila Transient Receptor Potential Channels
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    Last Updated: Apr 15, 2026

    Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
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    Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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    Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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  • Focus on high-resolution structural determination techniques.
  • Review of studies investigating TRP channel assembly and functional implications of structural findings.

    • Main Results:

    • Structures of 5 full-length TRP channels and 11 cytoplasmic domains have been determined.
    • Recent structural data provide detailed insights into the architecture of TRP channel complexes.
    • Structural information elucidates mechanisms of channel gating and modulation.

    Conclusions:

    • Structural biology has revolutionized the understanding of TRP channel function.
    • Continued structural studies are essential for deciphering TRP channel regulation and for therapeutic targeting.
    • The review emphasizes the rapid progress and future directions in TRP channel structural research.