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Physical activity is associated with cognitive processing speed in persons with multiple sclerosis.

Brian M Sandroff1, Deirdre Dlugonski1, Lara A Pilutti1

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 233 Freer Hall, 906 South Goodwin Avenue, Urbana 61801, IL, United States.

Multiple Sclerosis and Related Disorders
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PubMed
Summary

Physical activity, measured objectively, is linked to better cognitive processing speed (CPS) in multiple sclerosis (MS) patients. This finding suggests exercise may help manage cognitive function in MS.

Keywords:
AccelerometerCognitionCognitive processing speedMultiple sclerosisPhysical activityWalking performance

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Cognitive Neuroscience

Background:

  • Cognitive processing speed (CPS) impairment is a significant challenge in multiple sclerosis (MS).
  • Current management strategies for cognitive dysfunction in MS are limited.
  • Objective physical activity data is rarely linked to cognitive outcomes in MS.

Purpose of the Study:

  • To investigate the association between objectively measured physical activity and CPS in a large cohort of individuals with MS.
  • To determine if physical activity independently predicts CPS in MS.
  • To explore the relationship between physical activity, walking ability, and CPS in MS.

Main Methods:

  • A cohort of 212 persons with MS completed two validated CPS tests.
  • Objective physical activity was measured over 7 days using accelerometers (steps/day).
  • The Timed 25-Foot Walk (T25FW) assessed walking performance.

Main Results:

  • Physical activity demonstrated a significant positive association with CPS (r=.39, p<.01).
  • This association remained significant after controlling for age, sex, and education (pr=.26, p<.01).
  • The link between physical activity and CPS persisted, though attenuated, even after accounting for T25FW performance (pr=.13, p=.03).

Conclusions:

  • Objectively measured physical activity is positively and independently associated with CPS in persons with MS.
  • Physical activity may serve as a crucial behavioral intervention for managing cognitive processing speed deficits in MS.
  • These findings highlight the potential role of physical activity in improving cognitive outcomes in MS.